I don’t have much to say about Mushi-shi Sequel Series a.k.a. Mushishi Zoku Shou (Crunchyroll). I reviewed the original series here. I gave it 5 stars. The new season has the same cast, the same studio, the same look and the same kind of writing.
So anyone who liked the first season will probably feel the same way about the second. It’s a matter of taste, but I like it a lot.
Each episode is a self-contained story, which means that you don’t need to have watched the first season to enjoy the second. Since I consider it a classic I would recommend that you do watch the first season (it’s available on Hulu) but if you don’t you should still be able to follow the stories in the second season without much trouble.