Some people are fanatically devoted to this series. A few strongly dislike it. I fall somewhere in between. It’s not the greatest anime ever made, but I think it is pretty good; indeed the best example of its genre.
(The genre in question is “Seinen or Shounen Comedies about High School Girls Based on 4-koma Manga.” This is a larger category than you might expect.)
TitleAzumanga Daioh: The Animation 
Contents26 Episodes on 6 DVDs
LanguagesEnglish, Japanese with subtitles
Based onA 4-koma manga by Kiyohiko Azuma
Character DesignYasuhisa Kato
Chief Animation DirectorTakashi Wada
Animation StudioJ.C. Staff
BroadcastTV Tokyo, 2002
Region 1 PublisherADV Films
It is easy to see that this anime originated in short humorous comic strips. Each episode consists of a sequence of short comedy sketches. These are pretty funny in themselves, but on closer examination an overall story emerges: a rather affecting story about a group of misfits who gradually become friends and gain strength from their friendship. This is what gives the series its enduring appeal.
This series is not aimed at young children, but most of the material is fairly innocuous. Younger children may be bored but will probably not be upset by it.
There are two issues that may concern parents. One girl has a fairly innocent crush on another girl. And then there’s Mr. Kimura, who is enough to unnerve anyone with a daughter. Probably American children old enough to understand what is going on will not be too shocked, but this might be a good opportunity to have a talk about how to deal with inappropriate behavior by a teacher.
His appearance is particularly disturbing: he looks like a walking corpse, with a cadaverous face, sunken eyes and a slack jaw. The reason, of course, is that like everything else in this series he is shown from the girl’s perspective. They are pretty sure that they know what he is thinking and he creeps them out.
Anime News Network listing.
 The title is a combination of the names of the manga artist and Dengeki Daioh, the manga magazine in which the strips were published.
 Actually this is not totally impossible. There are a few cases on record of child prodigies who earned college degrees in their early teens. (List)